AFERsmart Plus™ Therapeutic Plasma Exchange, Double Filtration, Plasma Filtration-Adsorption, Therapeutic Apheresis able to perform double filtration-adsorption and hemoperfusion procedures Device. AFERsmart Plus™ can be used for both heparin and citrate therapies and allows in-line control of the plasma flow and integrated with an external heater (Kalos) It can be done. The pre-assembled kit makes the equipment easy to use.